How Fevers REALLY Work

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Fevers are one of our best weapons against infections, but they don't work like you might think.

We'd like to give a big thank you to Sharon Evans from the Roswell Park Comprehensive Cancer Center for sharing her expertise for this video!

LEARN MORE
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To learn more about this topic, start your googling with these keywords:
Fever: a rise in body temperature, usually caused by infection
Heat shock proteins (HSP): a family of proteins that are produced by cells in response to exposure to stressful conditions
Neutrophils: white blood cells that play an important role in inflammation and are early responders to pathogens.
T cells: major components of the adaptive immune system whose roles include regulating the immune response to pathogens.

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CREDITS
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Kate Yoshida | Script Writer, Narrator and Director
Arcadi Garcia i Rius (@garirius) | Illustration, Video Editing and Animation
Nathaniel Schroeder | Music

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REFERENCES
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Appenheimer, M.M. & Evans, S.S. (2018) Temperature and adaptive immunity. Handbook of Clinical Neurology 156: 397–415. https://linkinghub.elsevier.com/retrieve/pii/B978-0-444-63912-7.00024-2

Casadevall, A. (2016) Thermal Restriction as an Antimicrobial Function of Fever. PLoS Pathog 12(5): e1005577. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005577

ChangDong L. et al. (2019). Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. Immunity 50(1):137-151. https://www.cell.com/immunity/fulltext/S1074-7613(18)30495-3

Evans, S.S. et al. (2015) Fever and the thermal regulation of immunity: the immune system feels the heat. Nature Reviews Immunology 15(6): 335+. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786079/

Hasday, J.D., Thompson, C., Singh, I.S. (2014) Fever, immunity, and molecular adaptations. Comprehensive Physiology 4:109–48. https://onlinelibrary.wiley.com/doi/10.1002/cphy.c130019

Hasday, J.D. & Singh, I.S. (2000) Fever and the heat shock response: distinct, partially overlapping processes. Cell Stress Chaperones 5:471–480. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312879/

Javid, B., MacAry, P.A. & Lehner, P.J. (2007) Structure and function: heat shock proteins and adaptive immunity. Journal of Immunology 179:2035–2040. https://www.jimmunol.org/content/179/4/2035

Mackowiak, P. A.: Direct effects of hyperthermia on pathogenic microorganisms: teleological implications with regard to fever. Reviews of Infectious Diseases 1981, 3: 508–518. https://academic.oup.com/cid/article-abstract/3/3/508/307776