Why Does Wine Make Your Mouth Feel Dry?

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Astringent plant chemicals called tannins bind proteins on mucous membrane and skin, generating a prickly, puckery mouthfeel from foods and letting us “tan” skins into leather.
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If you want to learn more about this topic, start your googling here:
Tannin: a yellow or brownish chemical present in some plant tissues, used in leather production and ink manufacture, and a contributor to the sensation of astringency Astringency: the sensation caused by the contraction of body tissues due to tannins, often called “mouthfeel” Polyphenol: a chemical compound containing more than one phenolic hydroxyl group, of which tannins are a major group Phenolic: a chemical compound with a hydroxyl group (oxygen & hydrogen) linked directly to a benzene ring
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Credits (and Twitter handles):
Script Writer: Alex Reich (@alexhreich)
Script Editor: Kate Yoshida (@KateYoshida)
Video Illustrator: Ever Salazar (@eversalazar)
Video Director: Henry Reich (@MinutePhysics)
Video Narrator: Emily Elert (@eelert)
With Contributions From: Peter Reich, David Goldenberg
Music by: Nathaniel Schroeder: http://www.soundcloud.com/drschroeder

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References:

Bajec, M. R., & Pickering, G. J. 2008. Astringency: mechanisms and perception. Critical reviews in food science and nutrition, 48(9), 858-875. https://goo.gl/XLR0JY

Barbehenn, R. V., & Constabel, C. P. 2011. Tannins in plant–herbivore interactions. Phytochemistry, 72(13), 1551-1565. http://www.sciencedirect.com/science/article/pii/S0031942211000690

Covington, A. D. 1997. Modern tanning chemistry. Chemical Society Reviews, 26(2), 111-126. http://pubs.rsc.org/en/content/articlehtml/1997/cs/cs9972600111

Covington, A. D. 2009. Tanning chemistry: the science of leather. Royal Society of Chemistry.

Covington, A., Mar 2017, personal communication.

Gawel, R. 1998. Red wine astringency: a review. Australian Journal of Grape and Wine Research, 4(2), 74-95. http://onlinelibrary.wiley.com/doi/10.1111/j.1755-0238.1998.tb00137.x/full

Lesschaeve, I. & A.C. Noble. 2005. Polyphenols: factors influencing their sensory properties and their effects on food and beverage preferences. The American journal of clinical nutrition 81, no. 1: 330S-335S. http://ajcn.nutrition.org/content/81/1/330S.full

Siebert, K., Mar 2017, personal communication.