MinuteEarth

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It’s not just how much you take in; it’s how fast your body can purge it.

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To learn more about this topic, start your googling with these keywords:
Poison: A substance that is capable of causing illness or death when introduced or absorbed.
Overdose: A dangerously large dose of a substance.
Biotransformation: The process by which foreign chemicals are transformed by the body into less toxic substances.
Polydipsia: The medical term for feelings of extreme thirst that can lead to hyponatremia.
Hyponatremia: Abnormally low sodium in the blood often caused by excessive water consumption.
Lethal Concentration - The concentration a substance needs to be in the bloodstream to kill 50% of subjects.
Metabolism - the chemical processes that occur within a living organism in order to maintain life.
Toxicity - the quality of being toxic or poisonous.
Excretion - the process of eliminating or expelling waste matter.

SUPPORT MINUTEEARTH
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If you like what we do, you can help us!:
- Become our patron: https://patreon.com/MinuteEarth
- Share this video with your friends and family
- Leave us a comment (we read them!)

CREDITS
*********
Cameron Duke (@dukeofcam) | Script Writer
David Goldenberg (@dgoldenberg) | Narrator and Director
Arcadi Garcia i Rius (@garirius) | Illustration, Video Editing and Animation
Nathaniel Schroeder | Music

MinuteEarth is produced by Neptune Studios LLC
https://neptunestudios.info

OUR STAFF
************
Sarah Berman • Arcadi Garcia i Rius
David Goldenberg • Julián Gustavo Gómez
Melissa Hayes • Alex Reich • Henry Reich • Peter Reich
Ever Salazar • Leonardo Souza • Kate Yoshida

OUR LINKS
************
Youtube | https://youtube.com/MinuteEarth
TikTok | https://tiktok.com/@minuteearth
Twitter | https://twitter.com/MinuteEarth
Instagram | https://instagram.com/minute_earth
Facebook | https://facebook.com/Minuteearth

Website | https://minuteearth.com
Apple Podcasts| https://podcasts.apple.com/us/podcast/minuteearth/id649211176

REFERENCES
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ATSDR. (2006). Toxicological Profile for Cyanide. https://www.atsdr.cdc.gov/toxprofiles/tp8-c3.pdf

Cyanide Fact. (2013). Johns Hopkins Center for Health Security. https://www.centerforhealthsecurity.org/our-work/publications/cyanide-fact-sheet

Lead (Pb) Toxicity: What is the Biological Fate of Lead in the Body? | Environmental Medicine | ATSDR. (2021, February 9). Cdc.gov. https://www.atsdr.cdc.gov/csem/leadtoxicity/biologic_fate.html

Lethal Doses of Water, Caffeine and Alcohol. (2014, July 27). Compound Interest. https://www.compoundchem.com/2014/07/27/lethaldoses/

Radcliffe, S. (2017, May 25). How You Can Die From a Caffeine Overdose. Healthline; Healthline Media. https://www.healthline.com/health-news/how-you-can-die-from-caffeine#Caffeine-overdose-is-rare

Shalat, S. (2016, February 4). Toxic lead can stay in the body for years after exposure. The Conversation. https://theconversation.com/toxic-lead-can-stay-in-the-body-for-years-after-exposure-53607

Shenvi, C. (2016, February 16). Hydroxocobalamin: Turning Cyanide into Vitamin B12 | Emergency Physicians Monthly. Emergency Physicians Monthly | EPM. https://epmonthly.com/article/hydroxocobalamin-turning-cyanide-into-vitamin-b12/

Direct download: Why_Poison_Sometimes_Doesnt_Kill_You.mp4
Category:general -- posted at: 3:44pm EDT

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Optimal foraging theory means that turning down food is sometimes more efficient than eating it - but even then, what’s “wasted” doesn’t necessarily go to waste.

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To learn more about this topic, start your googling with these keywords:
Foraging: to search widely for food.
Optimal Foraging Theory: A behavioral model that describes how an animal should behave when searching for food.
Surplus Killing: a common behavior exhibited by predators, in which they kill more prey than they can immediately eat and then cache or abandon the remainder.

SUPPORT MINUTEEARTH
**************************
If you like what we do, you can help us!:
- Become our patron: https://patreon.com/MinuteEarth
- Share this video with your friends and family
- Leave us a comment (we read them!)

CREDITS
*********
Cameron Duke | Script Writer
Kate Yoshida | Script Editor
Julián Gustavo Gómez | Narrator and Director
Adam Thompson | Illustration, Video Editing and Animation
Nathaniel Schroeder | Music

MinuteEarth is produced by Neptune Studios LLC
https://neptunestudios.info

OUR STAFF
************
Sarah Berman • Arcadi Garcia i Rius
David Goldenberg • Julián Gustavo Gómez
Melissa Hayes • Alex Reich • Henry Reich • Peter Reich
Ever Salazar • Leonardo Souza • Kate Yoshida

OUR LINKS
************
Youtube | https://youtube.com/MinuteEarth
TikTok | https://tiktok.com/@minuteearth
Twitter | https://twitter.com/MinuteEarth
Instagram | https://instagram.com/minute_earth
Facebook | https://facebook.com/Minuteearth

Website | https://minuteearth.com
Apple Podcasts| https://podcasts.apple.com/us/podcast/minuteearth/id649211176

REFERENCES
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Alcock, J. (2013). Animal behavior : an evolutionary approach. Sinauer, Cop.

Hopkins, J. B. (2013). Use of genetics to investigate socially learned foraging behavior in free-ranging black bears. Journal of Mammalogy, 94(6), 1214–1222. https://doi.org/10.1644/13-mamm-a-009.1

Klinka, D. R., & Reimchen, T. E. (2009). Darkness, Twilight, and Daylight Foraging Success of Bears (Ursus americanus) on Salmon in Coastal British Columbia. Journal of Mammalogy, 90(1), 144–149. https://doi.org/10.1644/07-mamm-a-200.1

Lincoln, A. E., & Quinn, T. P. (2018). Optimal foraging or surplus killing: selective consumption and discarding of salmon by brown bears. Behavioral Ecology, 30(1), 202–212. https://doi.org/10.1093/beheco/ary139

Lounibos, L. P., Makhni, S., Alto, B. W., & Kesavaraju, B. (2008). Surplus Killing by Predatory Larvae of Corethrella appendiculata: Prepupal Timing and Site-Specific Attack on Mosquito Prey. Journal of Insect Behavior, 21(2), 47–54. https://doi.org/10.1007/s10905-007-9103-2

Maupin, J. L. (2001). Superfluous killing in spiders: a consequence of adaptation to food-limited environments? Behavioral Ecology, 12(5), 569–576. https://doi.org/10.1093/beheco/12.5.569

McMahon, B. F., & Evans, R. M. (1992). Foraging Strategies of American White Pelicans. Behaviour, 120(1-2), 69–89. https://doi.org/10.1163/156853992x00219

Direct download: Why_These_Bears_Waste_Food.mp4
Category:general -- posted at: 10:46pm EDT

Watch the new season of MinuteBody - and get access to both CuriosityStream and Nebula - at https://curiositystream.com/minuteearth.
Fevers are one of our best weapons against infections, but they don't work like you might think.

We'd like to give a big thank you to Sharon Evans from the Roswell Park Comprehensive Cancer Center for sharing her expertise for this video!

LEARN MORE
**************
To learn more about this topic, start your googling with these keywords:
Fever: a rise in body temperature, usually caused by infection
Heat shock proteins (HSP): a family of proteins that are produced by cells in response to exposure to stressful conditions
Neutrophils: white blood cells that play an important role in inflammation and are early responders to pathogens.
T cells: major components of the adaptive immune system whose roles include regulating the immune response to pathogens.

SUPPORT MINUTEEARTH
**************************
If you like what we do, you can help us!:
- Become our patron: https://patreon.com/MinuteEarth
- Share this video with your friends and family
- Leave us a comment (we read them!)

CREDITS
*********
Kate Yoshida | Script Writer, Narrator and Director
Arcadi Garcia i Rius (@garirius) | Illustration, Video Editing and Animation
Nathaniel Schroeder | Music

MinuteEarth is produced by Neptune Studios LLC
https://neptunestudios.info

OUR STAFF
************
Sarah Berman • Arcadi Garcia i Rius
David Goldenberg • Julián Gustavo Gómez
Melissa Hayes • Alex Reich • Henry Reich • Peter Reich
Ever Salazar • Leonardo Souza • Kate Yoshida

OUR LINKS
************
Youtube | https://youtube.com/MinuteEarth
TikTok | https://tiktok.com/@minuteearth
Twitter | https://twitter.com/MinuteEarth
Instagram | https://instagram.com/minute_earth
Facebook | https://facebook.com/Minuteearth

Website | https://minuteearth.com
Apple Podcasts| https://podcasts.apple.com/us/podcast/minuteearth/id649211176

REFERENCES
**************
Appenheimer, M.M. & Evans, S.S. (2018) Temperature and adaptive immunity. Handbook of Clinical Neurology 156: 397–415. https://linkinghub.elsevier.com/retrieve/pii/B978-0-444-63912-7.00024-2

Casadevall, A. (2016) Thermal Restriction as an Antimicrobial Function of Fever. PLoS Pathog 12(5): e1005577. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005577

ChangDong L. et al. (2019). Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. Immunity 50(1):137-151. https://www.cell.com/immunity/fulltext/S1074-7613(18)30495-3

Evans, S.S. et al. (2015) Fever and the thermal regulation of immunity: the immune system feels the heat. Nature Reviews Immunology 15(6): 335+. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786079/

Hasday, J.D., Thompson, C., Singh, I.S. (2014) Fever, immunity, and molecular adaptations. Comprehensive Physiology 4:109–48. https://onlinelibrary.wiley.com/doi/10.1002/cphy.c130019

Hasday, J.D. & Singh, I.S. (2000) Fever and the heat shock response: distinct, partially overlapping processes. Cell Stress Chaperones 5:471–480. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312879/

Javid, B., MacAry, P.A. & Lehner, P.J. (2007) Structure and function: heat shock proteins and adaptive immunity. Journal of Immunology 179:2035–2040. https://www.jimmunol.org/content/179/4/2035

Mackowiak, P. A.: Direct effects of hyperthermia on pathogenic microorganisms: teleological implications with regard to fever. Reviews of Infectious Diseases 1981, 3: 508–518. https://academic.oup.com/cid/article-abstract/3/3/508/307776

Direct download: How_Fevers_REALLY_Work.mp4
Category:general -- posted at: 9:54pm EDT

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